Anti-CD109抗体CD109 is a a novel member of the alpha2-macroglobulin （alpha2M）/complement superfamily.

产品编号 yb-6067R
英文名称 Anti-CD109抗体
中文名称 转化生长因子β1结合蛋白抗体
别    名 p180; 8A3; 150 KDa TGF beta 1 binding protein; 7D1; DKFZp762L1111; E123; Plaet specific Gov antigen; r150; RP11 525G3.1; Activated T cell marker CD109; CD 109 antibody CD109 antigen; CPAMD7; FLJ38569; FLJ41966; Gov system alloantigens on plaets.
Anti-CD109抗体  
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  免疫学  细胞表面分子  糖蛋白  淋巴细胞  t-淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 154kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD109
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4
PubMed PubMed
产品介绍 background:
CD109 is a a novel member of the alpha2-macroglobulin (alpha2M)/complement superfamily. It is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein of approximay 170 kd found on endothelial cells, activated plaets and T-cells and on a subset of hematopoietic stem and progenitor cells. Although it has been suggested that T-cell CD109 may play a role in antibody-inducing T-helper function and it is known that plaet CD109 carries the Gov alloantigen system, the role of CD109 in hematopoietic cells remains largely unknown. CD109 has been identified as part of the TGF-beta receptor system in human keratinocytes and upregulation of CD109 expression has been observed in several different types of tumour.

Function:
Modulates negatively TGFB1 signaling in keratinocytes.

Subunit:
Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated plaets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.

Post-translational modifications:
N-glycosylated.
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. 

Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.