Anti-CTHRC1抗体CCTHRC1 is a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling.

产品编号 yb-5882R
英文名称 Anti-CTHRC1抗体
中文名称 胶原三股螺旋重复蛋白1抗体
别    名 Collagen triple helix repeat containing 1; Collagen triple helix repeat containing protein 1; Collagen triple helix repeat-containing protein 1; CTHR1_HUMAN; Cthrc1; NMTC1 protein; Protein NMTC1.
Anti-CTHRC1抗体 
说 明 书 0.2ml  
研究领域 肿瘤  心血管  免疫学  信号转导  生长因子和激素  细胞骨架  细胞外基质  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
细胞定位 细胞外基质 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CTHRC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
CTHRC1 is a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.

Function:
May act as a negative regulator of collagen matrix deposition (By similarity). 

Subcellular Location:
Secreted, extracellular space, extracellular matrix (By similarity).

Tissue Specificity:
Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.

Post-translational modifications:
N-glycosylated (By similarity). 

DISEASE:
Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 

Similarity:
Contains 1 collagen-like domain. 

Database links:
UniProtKB/Swiss-Prot: Q96CG8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.