Anti-CNTROB抗体CNTROB is a centrosomal protein that interacts with BRCA2 and is required for centriole duplication with inhibition of centriole duplication leading to defects in cytokinesis.

产品编号 yb-4299R
英文名称 CAnti-CNTROB抗体
中文名称 乳腺癌易感基因2相互作用蛋白抗体
别    名 Centrobin; centrobin, centrosomal BRCA2 interacting protein; Centrosomal BRCA2 interacting protein; LIP8; LYST interacting protein 8; CNTRB_HUMAN.
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说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  免疫学  细胞周期蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 101kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CNTROB
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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PubMed PubMed
产品介绍 background:
CNTROB is a centrosomal protein that interacts with BRCA2 and is required for centriole duplication with inhibition of centriole duplication leading to defects in cytokinesis.

Function:
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.

Subunit:
Interacts with LYST.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.

Tissue Specificity:
Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

Database links:
UniProtKB/Swiss-Prot: Q8N137.1
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Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.