Anti-CCDC85B抗体Hepatitis delta virus （HDV） is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A （DIPA）,

产品编号 yb-10390R
英文名称 Anti-CCDC85B抗体
中文名称 卷曲螺旋结构域蛋白85B抗体
别    名 Ccdc85b; Coiled coil domain containing 85B; Coiled-coil domain-containing protein 85B; Delta interacting protein A; Delta-interacting protein A; DIPA; Hepatitis delta antigen interacting protein A; Hepatitis delta antigen-interacting protein A; CC85B_HUMAN.
Anti-CCDC85B抗体
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  染色质和核信号  微生物学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CCDC85B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008].

Function:
Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion.

Subunit:
Interacts with CEBPB (By similarity). May interact with CEBPD. Interacts with MCRS1. Interacts with TCF7L2; competes with CTNNB1. Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG). This interaction affects viral genomic replication in intact cells.

Subcellular Location:
Nucleus. Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Widely expressed including liver.

Similarity:
Belongs to the CCDC85 family.

Database links:
NCBI Reference Sequence: NP_006839.2 
UniProtKB/Swiss-Prot: Q15834.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.