Anti-Ceruloplasmin抗体又称铜氧化酶，是一种含铜的α2糖蛋白，CER具有氧化酶的活性，起着抗氧化剂的作用。

产品编号 yb-2373R
英文名称 Anti-Ceruloplasmin抗体
中文名称 铜蓝蛋白抗体
别    名 CER; caeruloplasmin; Ceruloplasmin precursor; CP 2; CP; CP2; CP-2; EC 1.16.3.1; Ferroxidase.
Anti-Ceruloplasmin抗体 
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  心血管  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ceruloplasmin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Caeruloplasmin is a copper binding plasma glycoprotein consisting of a single polypeptide chain. It has a molecular weight of 132kDa and occurs in plasma at a concentration of 150-500 mg/L. Although the physiological functions of Caeruloplasmin are not fully understood it is implicated in a number of possible functions. 95% of plasma copper is bound to Caeruloplasmin, implying some involvement in copper transport. Caeruloplasmin has been described as both an oxidant and an antioxidant, its exact role or roles in this respect are not clear. Plasma levels of Caeruloplasmin are elevated after inflammation and trauma and it is therefore classified as an acute phase protein. The measurement of Caeruloplasmin in plasma is useful in the diagnosis of Wilson’s disease, where levels are greatly reduced. Caeruloplasmin is extremely labile in plasma and rapidly degrades to 115kDa and 19kDa fragments. The age of plasma samples should therefore be taken into account when interpreting immunological analysis of caeruloplasmin.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

   又称铜氧化酶，是一种含铜的α2糖蛋白，CER具有氧化酶的活性，起着抗氧化剂的作用。在血循环中CER的抗氧化活力可以防止组织中脂质过氧化物和自由基的生成，特别在炎症时具有重要意义,也属于一种急性时相反应蛋白。
    铜蓝蛋白对多酚及多胺类底物有催化其氧化之能力铜蓝蛋白具有遗传上的基因多形性。其作用为调节铜在机体各个部位的分布、合成含铜的酶蛋白.一般认为铜蓝蛋白由肝脏合成，一部分由胆道排泄，尿中含量甚微。铜蓝蛋白测定对某些肝、胆、肾等疾病的诊断有一定意义。