Anti-CROT抗体CROT （Carnitine O-octanoyltransferase） is involved in the beta-oxidation of fatty acids. It catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine.

产品编号 yb-5048R
英文名称 Anti-CROT抗体
中文名称 肉碱氧位甲基转移酶抗体
别    名 Carnitine O octanoyltransferase; COT; CROT; OCTC_HUMAN; Peroxisomal carnitine acyltransferase; Peroxisomal carnitine O octanoyltransferase; Peroxisomal carnitine O-octanoyltransferase.
Anti-CROT抗体 
说 明 书 0.2ml  
研究领域 心血管  细胞生物  免疫学  染色质和核信号  信号转导  细胞类型标志物  脂蛋白  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CROT
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
CROT (Carnitine O-octanoyltransferase) is involved in the beta-oxidation of fatty acids. It catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. It has highest activity towards the C6 to C10 chain length substrate. It is a crucial step in the transport of medium- and long-chain acyl-CoA out of the mammalian peroxisome to the cytosol and mitochondria.

Function:
Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. 

Subunit:
Monomer (Probable). 

Subcellular Location:
Peroxisome.

Similarity:
Belongs to the carnitine/choline acetyltransferase family. 

Database links:
UniProtKB/Swiss-Prot: Q9UKG9.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.