Anti-CKLF抗体是人类趋化素样因子超家族CKLFSF（Chemokine-like Factor Super Family，趋化素样因子超家族）中的一员，趋化因子能使细胞发生趋化运动的小分子细胞因子。

产品编号 yb-2394R
英文名称 Anti-CKLF抗体
中文名称 趋化素样蛋白抗体
别    名 C32; Chemokine-like factor; chemokine-like factor 1; chemokine-like factor 2; chemokine-like factor 3; chemokine-like factor 4; CKLF_HUMAN; CKLF1; CKLF2; CKLF3; CKLF4; CKLFSF2; HSPC224; transmembrane proteolipid; UCK-1; UCK1.
Anti-CKLF抗体 
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  细胞分化  淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
细胞定位 细胞膜 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CKLF
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
CKLF is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. CKLF protein is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. CKLF may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified.

Function:
May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.
Isoform 1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes. 

Subcellular Location:
Isoform 1: Secreted.
Isoform 2: Membrane; Multi-pass membrane protein.
Isoform 4: Membrane; Multi-pass membrane protein.

Tissue Specificity:
Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver.

Similarity:
Belongs to the chemokine-like factor family.
Contains 1 MARVEL domain.

Database links:
UniProtKB/Swiss-Prot: Q9UBR5.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

（趋化素样因子）是人类趋化素样因子超家族CKLFSF（Chemokine-like Factor Super Family，趋化素样因子超家族）中的一员，趋化因子能使细胞发生趋化运动的小分子细胞因子。趋化因子结构和功能比较相似,分子量多在10-20kDa之间,对嗜中性粒细胞、淋巴细胞、单核细胞等多种细胞有趋化活性。