Anti-CETP抗体系一疏水糖蛋白，*酯转运蛋白--介导HDL中的*与VLDL中的甘油三酯等交换，促进HDL中的*净转运，可促进*酯在细胞与血浆脂蛋白间的转运，参与*的逆转运过程。

产品编号 byb-3694R
英文名称 Anti-CETP抗体
中文名称 *酯转移蛋白抗体
别    名 BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; Cholesteryl ester transfer protein precursor; HDLCQ10; Lipid transfer protein I.
Anti-CETP抗体    
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  心血管  细胞生物  免疫学  信号转导  脂蛋白  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
细胞定位 细胞外基质 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CETP
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
High density lipoproteins (HDLs) have been proposed to function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.

Function:
Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. 

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Expressed by the liver and secreted in plasma.

DISEASE:
Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).

Similarity:
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Database links:
UniProtKB/Swiss-Prot: P11597.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

系一疏水糖蛋白，*酯转运蛋白--介导HDL中的*与VLDL中的甘油三酯等交换，促进HDL中的*净转运，可促进*酯在细胞与血浆脂蛋白间的转运，参与*的逆转运过程。