Anti-ANKK1抗体The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an

产品编号 yb-12475R
英文名称 Anti-ANKK1抗体
中文名称 锚定蛋白重复结构域蛋白激酶ANKK1抗体
别    名 Ankyrin repeat and kinase domain containing 1; Ankyrin repeat and protein kinase domain containing protein 1; EC 2.7.11.1; PKK2; Protein kinase PKK2; SGK288; Sugen kinase 288; X kinase; ANKK1_HUMAN.
Anti-ANKK1抗体
说 明 书 0.2ml  
研究领域 信号转导  细胞凋亡  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 85kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ANKK1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimay involved in this process are the serine/threonine (Ser/Thr) protein kinases. ANKK1 (ankyrin repeat and kinase domain containing 1), also known as PKK2 or SGK288, is a 765 amino acid protein that belongs to the Ser/Thr protein kinase family and contains 12 ANK repeats and one protein kinase domain. Highly expressed in brain tissue and present in lower amounts in placenta and spinal cord, ANKK1 functions to catalyze the ATP-dependent phosphorylation of target proteins and is thought to play a role in alcohol and nicotine dependence. The gene encoding ANKK1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.

Function:
ANKK1 belongs to the TKL Ser/Thr protein kinase superfamily, contains twelve ANK repeats and one protein kinase domain. The protein is weakly expressed in testis, placenta, and spinal cord.

Tissue Specificity:
Highly expressed in brain and weakly expressed in placenta and spinal cord.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 
Contains 12 ANK repeats.
Contains 1 protein kinase domain.

Database links:
UniProtKB/Swiss-Prot: Q8NFD2.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.