Anti-ASH1L抗体ASH1L is a 2,969 amino acid protein encoded by the human gene ASH1L. ASH1L belongs to the histone-lysine methyltransferase family （SET2 subfamily） and contains three AT hook DNA-binding do

产品编号 yb-9671R
英文名称 Anti-ASH1L抗体
中文名称 ASH1蛋白抗体
别    名 Absent small and homeotic disks protein 1 homolog; Absent Small or Homeotic Like; ASH 1; ASH 1L; ash1 (absent small or homeotic 1); Ash1 (absent small or homeotic) like; Absent small and homeotic disks protein 1 homolog; ASH1-like protein; ASH-1L; ASH1L_HUMAN; ASH1L1; huASH1; Lysine N-methyltransferase 2H; Probable histone-lysine N-methyltransferase ASH1L.
Anti-ASH1L抗体    
说 明 书 0.2ml  
研究领域 细胞生物  神经生物学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, 
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 327kDa
细胞定位 细胞核 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ASH1L
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
ASH1L is a 2,969 amino acid protein encoded by the human gene ASH1L. ASH1L belongs to the histone-lysine methyltransferase family (SET2 subfamily) and contains three AT hook DNA-binding domains, one AWS domain, one BAH domain, one bromodomain, one PHD-type zinc finger, one post-SET domain and one SET domain. It is a widely expressed nuclear protein with highest expression found in brain, heart and kidney. ASH1L is a histone methyltransferase and is believed to methylate 'Lys-4' of Histone H3, which is a specific tag for epigenetic transcriptional activation.

Function:
Histone methyltransferase. Probably methylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation.

Subcellular Location:
Nucleus. Cell junction, tight junction. Chromosome (Probable). Note=The relevance of tight junction localization is however unclear.

Tissue Specificity:
Widely expressed, with highest level in brain, heart and kidney.

Similarity:
Belongs to the histone-lysine methyltransferase family. SET2 subfamily. 
Contains 3 A.T hook DNA-binding domains.
Contains 1 AWS domain. 
Contains 1 BAH domain. 
Contains 1 bromo domain. 
Contains 1 PHD-type zinc finger. 
Contains 1 post-SET domain. 
Contains 1 SET domain.



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.