Anti-APLP2抗体Apurinic/apyrimidinic （AP） sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific

产品编号 yb-8462R
英文名称 Anti-APLP2抗体
中文名称 淀粉样蛋白β前体样蛋白2抗体
别    名 amyloid beta (A4) precursor like protein 2; Amyloid like protein 2; amyloid precursor protein homolog HSD2; Amyloid protein homolog; Amyloid-like protein 2; APLP-2; Aplp2; APLP2_HUMAN; APPH; APPL2; CDEBP; CDEI box binding protein; CDEI box-binding protein.
 Anti-APLP2抗体 
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  神经生物学  Alzheimer's  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
细胞定位 细胞核 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human APLP2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
APLP2 is a human sperm membrane protein which contains a segment with high homology to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer disease patients. The human amyloid precursor-like protein APLP2 is a highly conserved homolog of a sequence-specific DNA-binding mouse protein with an important function in the cell cycle. The gene which encodes APLP2 maps to human chromosome 11q24.
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.

Function:
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.

Subunit:
Interacts with CPEB1.

Subcellular Location:
Cell membrane. Nucleus.

Tissue Specificity:
Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

Post-translational modifications:
The BPTI/Kunitz inhibitor domain is O-glycosylated.

Similarity:
Belongs to the APP family.
Contains 1 BPTI/Kunitz inhibitor domain. 
 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.