Anti-ATE1抗体ATE1, also known as arginyltransferase 1, is an enzyme that is involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein.

产品编号 bs-7973R
英文名称 Anti-ATE1抗体
中文名称 *tRNA的蛋白转移酶1抗体
别    名 Arginine tRNA protein transferase 1; Arginyl-tRNA--protein transferase 1; Arginyl-tRNA-protein transferase; Arginyltransferase 1; R transferase 1; EC 2.3.2.8; AI225793; ATE1_HUMAN.
Anti-ATE1抗体 
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ATE1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
ATE1, also known as arginyltransferase 1, is an enzyme that is involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. There are two named isoforms.

Function:
Involved in the post-translational conjugation ofarginine to the N-terminal aspartate or glutamate of a protein.This arginylation is required for degradation of the protein viathe ubiquitin pathway. Does not arginylate cysteine residues (Bysimilarity).

Subunit:
Monomer (Potential). 

Subcellular Location:
Isoform ATE1-1: Nucleus (By similarity).Cytoplasm (By similarity). 
Isoform ATE1-2: Cytoplasm (By similarity).

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. 

Similarity:
Belongs to the R-transferase family. 

Database links:
UniProtKB/Swiss-Prot: O95260.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.