Anti-ABCA5抗体ABCA5 is a member of the superfamily of ATP binding cassette （ABC） transporters. ABC proteins transport various molecules across extra and intracellular membranes.

产品编号 yb-7940R
英文名称 Anti-ABCA5抗体
中文名称 三磷酸腺苷结合盒转运蛋白A亚基5抗体
别    名 ABC13; ATP binding cassette sub family A (ABC1) member 5; ATP binding cassette A5; ATP binding cassette sub family A member 5; DKFZp451F117; DKFZp779N2435; EST90625; FLJ16381; KIAA1888; ABCA5_HUMAN.
Anti-ABCA5抗体   
说 明 书 0.2ml  
研究领域 细胞生物  细胞周期蛋白  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 186kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABCA5
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
ABCA5 is a member of the superfamily of ATP binding cassette (ABC) transporters. ABC proteins transport various molecules across extra and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). ABCA5 is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. ABCA5 is localized in the lysosome, late endosome and Golgi apparatus membrane and is thought to play a role in the processing of autolysosomes.

Function:
May play a role in the processing of autolysosomes (By similarity). 

Subcellular Location:
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein (By similarity). 

Tissue Specificity:
Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. 

Post-translational modifications:
N-glycosylated (By similarity). 

Similarity:
Belongs to the ABC transporter superfamily. ABCA family. 
Contains 2 ABC transporter domains. 

Database links:
UniProtKB/Swiss-Prot: Q8WWZ7.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.