Anti-ABCA9抗体ABCA9 is a member of the superfamily of ATP-binding cassette （ABC） transporters and contains two transmembrane domains and two nucleotide binding folds.

产品编号 yb-7853R
英文名称 Anti-ABCA9抗体
中文名称 三磷酸腺苷结合盒转运蛋白9抗体
别    名 ATP binding cassette A9; ATP binding cassette sub family A (ABC1) member 9; ATP binding cassette sub family A member 9; DKFZp686F2450; EST640918; MGC75415; ABCA9_HUMAN.
Anti-ABCA9抗体
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  信号转导  细胞周期蛋白  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 184kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABCA9
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
ABCA9 is a member of the superfamily of ATP-binding cassette (ABC) transporters and contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). ABCA9 is a member of the ABC1 subfamily and is clustered with four other ABC1 family members on chromosome 17q24. Transcriptional expression of the ABCA9 gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import. ABCA9 May play a role in monocyte differentiation and lipid homeostasis.

Function:
May play a role in monocyte differentiation and lipidhomeostasis. 

Subcellular Location:
Membrane; Multi-pass membrane protein(Potential). 

Tissue Specificity:
Widely expressed with higher expression inheart.

Similarity:
Belongs to the ABC transporter superfamily. ABCAfamily.
Contains 2 ABC transporter domains. 

Database links:
UniProtKB/Swiss-Prot: Q8IUA7.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.