Anti-ABCA2抗体The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette （ABC） transporters.

产品编号 yb-6332R
英文名称 Anti-ABCA2抗体
中文名称 三磷酸腺苷结合盒转运蛋白2抗体
别    名 ABC2; ATP binding cassette 2; ATP binding cassette sub family A member 2; ATP binding cassette transporter 2; ATP binding cassette, sub family A (ABC1), member 2; ATP binding cassette, sub family A, member 2; ATP binding cassette, sub family B (MDR/TAP), member 2;ABCA2_HUMAN.
Anti-ABCA2抗体   
说 明 书 0.1ml  0.2ml  
研究领域 心血管  细胞生物  免疫学  神经生物学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, 
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 270kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABCA2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene (from EntrezGene).

Function:
Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.

Subcellular Location:
Endosome. Membrane. Lysosome. Membrane. Forms discrete, punctate intracellular vesicles.

Tissue Specificity:
Highy expressed in the brain, whereas lower levels of expression is observed in kidney and liver.

Similarity:
Belongs to the ABC transporter superfamily. ABCA family.
Contains 2 ABC transporter domains.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.