Anti-ADAM18抗体ADAM18 was first described as tMDC III （testis-specific Metalloproteinase-like disintergin-like cysteine-rich protein-III）.

产品编号 yb-5849R
英文名称 Anti-ADAM18抗体
中文名称 去整合素样金属蛋白酶18抗体
别    名 A disintegrin and metalloproteinase domain 18; ADAM 18; ADA18_HUMAN; ADAM 27; ADAM metallopeptidase domain 18; ADAM27; MGC41836; MGC88272; TMDC3; tMDCIII; Transmembrane metalloproteinase like, disintegrin like, and cysteine rich protein III.
Anti-ADAM18抗体   
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  信号转导  细胞骨架  细胞外基质  泛素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Dog, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADAM18
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
ADAM18 was first described as tMDC III (testis-specific Metalloproteinase-like disintergin-like cysteine-rich protein-III). ADAM18 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the fill-length ADAM18 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a short spacer region, then the transmembrane domain and a cytoplasmic domain. Like many of the reproductive-specific ADAMS, ADAM18 plays a nonenzymatic role, or (as is the case for ADAMs 1 & 2 (fertilin alpha and beta)), the protein acts in concert with a proteolytically active ADAM to process proteins. Little is known about interactions between ADAM18 and other ADAMs. To date, 4 different sequences for human ADAM18 are published; 739, 715, 182 and 153 amino acids in length.

Function:
Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein.

Subcellular Location:
Membrane; Single-pass type I membrane protein. 

Tissue Specificity:
Expressed specifically in testis. 

Post-translational modifications:
The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa.

Similarity:
Contains 1 disintegrin domain. 
Contains 1 EGF-like domain. 
Contains 1 peptidase M12B domain. 


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.