Anti-AIMP2抗体是新近发现的纤维蛋白溶解酶原（PLG）和组织型纤溶蛋白溶解酶原激活物（t-PA）的共受体,是Ca2+介导具有高亲和力的磷脂结合蛋白.其介导血管内外纤维蛋白溶解,对保持机体内环境稳定具有重要作用.

产品编号 yb-2509R
英文名称 Anti-AIMP2抗体
中文名称 AIMP2抗体
别    名 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Aimp2; AA407136; AA407225; Aimp2(p38); JTV 1 protein; Jtv1; MGC30261; MGC36346; MGC36522; MGC37389; ARS interacting multi functional protein 2; Multisynthetase complex auxiliary component p38; P38; tRNA SYNTHETASE COFACTOR p38; PRO0992; Protein JTV 1; JTV-1; JTV1; P38; PRO0992; AIMP2_HUMAN.
Anti-AIMP2抗体  
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AIMP2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
P38 is a probable core protein of the multisynthetase complex that serves as a template for the assembly of the supramolecular structure. Mediates ubiquitination of FUBP1 and its degradation by the proteasome. P38 is also a cofactor of multi-ARS complex and also a substrate of parkin in neuronal cell.

Function:
Required for assembly and stability of the minoacyl-tRNA synthase complex. Mediates ubiquitination and egradation of FUBP1, a transcriptional activator of MYC, leading o MYC down-regulation which is required for aveolar type II cell ifferentiation. Blocks MDM2-mediated ubiquitination and egradation of p53/TP53. Functions as a proapoptotic factor.

Subunit:
Component of the aminoacyl-tRNA synthase complex which is omprised of a bifunctional glutamyl-prolyl-tRNA synthase, the onospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, rginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). nteracts in both its unphosphorylated and phosphorylated forms ith p53/TP53 (via N-terminus) in the nucleus following UV rradiation. Interacts (via N-terminus) with KARS and PARK2/parkin via first RING-type domain).

Subcellular Location:
Cytoplasm, cytosol (By similarity). Nucleus By similarity). Note=Following DNA damage, dissociates from the minoacyl-tRNA synthase complex and translocates from the cytoplasm o the nucleus (By similarity).

Post-translational modifications:
Phosphorylated on serine residues in response to UV rradiation (By similarity). 
Ubiquitinated by PARK2, leading to its degradation by the roteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, llowing its accumulation which may contribute to neurodegeneration ssociated with Parkinson disease.

Similarity:
Contains 1 GST C-terminal domain.