Anti-ATTY抗体（腺苷受体A3）属于G蛋白偶联受体家族，在腺苷调节细胞活力和生长中起关键作用，并且在很多肿瘤中表达增高，A3AR可能成为肿瘤诊断标志物和治疗靶点。

产品编号 YB-1907R
英文名称 Anti-ATTY抗体
中文名称 细胞*转氨酶抗体
别    名 TYROSINE AMINOTRANSFERASE; tyrosine aminotransferase; MGC37772; MGC37789; MGC37790; MGC37819; MGC37828; MGC37842; TAT; ATTY_HUMAN; L-tyrosine:2-oxoglutarate aminotransferase; TAT; Tyrosine aminotransferase; Tyrosine aminotransferase, cytosolic.
Anti-ATTY抗体  
说 明 书 0.2ml  
研究领域 细胞生物  神经生物学  信号转导  激酶和磷酸酶  合成与降解  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Tat
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked.

Function:
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has no transaminase activity towards phenylalanine.

Subunit:
Homodimer (Probable).

DISEASE:
Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.

Similarity:
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.