Anti-ABP抗体雄激素结合蛋白ABP是一种由睾丸支持细胞合成和分泌的与雄激素有高度亲和力的蛋白,雄激素是依赖于雄激素结合蛋白起作用的,ABP与睾酮或双氢睾酮结合后，转运至曲细精管，提高雄激素在曲细精管的局部浓度，有利于生精过程。

产品编号 yb-2410R
英文名称 Anti-ABP抗体
中文名称 雄激素结合蛋白抗体
别    名 Androgen binding protein; MGC126834; MGC138391; SBP; Sex steroid binding protein; SHBG; TEBG; Testis specific androgen binding protein; Testosterone binding beta globulin; Testosterone Estradiol Binding Globulin; Testosterone estrogen binding globulin; UniProtKB/Swiss-Prot: P04278.2; SHBG_HUMAN.
 Anti-ABP抗体 
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  生长因子和激素  内分泌病  结合蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
细胞定位 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABP
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
Sex hormone binding globulin (SHBG) is a glycoprotein synthesized by the liver. Circulating androgen and estrogen concentrations influence SHBG synthesis. Elevated testosterone, for example, causes SHBG synthesis to decrease, whereas high estrogen stimulates SHBG production. The regulation of SHBG synthesis, combined with SHBG's higher affinity for testosterone, impacts bioavailable testosterone levels. SHBG binds up to 98 percent of the steroid hormones in the blood including 5a-dihydrotestosterone (DHT), testosterone and androstenediol with particularly high affinity, and estradiol and estrone with slightly lower affinity.

Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Subunit:
Homodimer.

Subcellular Location:
Secreted (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity).

Tissue Specificity:
Isoform 1 and isoform 2 are present in liver and testis.

Similarity:
Contains 2 laminin G-like domains.

 
雄激素结合蛋白ABP是一种由睾丸支持细胞合成和分泌的与雄激素有高度亲和力的蛋白,雄激素是依赖于雄激素结合蛋白起作用的,ABP与睾酮或双氢睾酮结合后，转运至曲细精管，提高雄激素在曲细精管的局部浓度，有利于生精过程。